Hello Gemfall5,
Sorry to hear that you're having problems with saving your changes. When you're working in IE10, make sure that the compatibility button is selected. Also, if you have no changes made on the page, then the SAVE CHANGES button will not be available.
Check out this article for more info on IE10 Compatibility: Internet Explorer 10 Compatibility with Web Builder.
If your issue is not with the Builder, please give us more detail on the problem and we would be glad to help.
If you have any further questions, please contact technical support available 24 hours a day / 7 days a week.
Regards,
Arnel C.
Community Support